Clinical Significance :
Elevated alanine aminotransferase (ALT) values are seen in parenchymal liver diseases characterized by a destruction of hepatocytes. Values are at least 10 times higher the normal range and may reach up to 100 times the upper reference limit. Commonly, values are seen to be 20 - 50 times higher than normal. In infectious hepatitis and other inflammatory conditions affecting the liver.
Clinical Significance :
Serum glutamic oxaloacetic transaminase(SGOT), an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGOT levels. .
INTERPRETATION OF RESULT
• Agglutination is a positive test result. The titre of the patient serum corresponds to the visible agglutination in the test Circle with the smallest amount of serum sample.
• Agglutinin titre greater than 1:80 is considered as significant infection and low titres indicate absence of infection
REMARK
1.Positive results obtained in the slide test should be confirmed with the tube test to establish whether the titres are diagnostically significant or not.
2.TAB vaccinated patients may show a high titre of antibodies to each of the antigens. Similarly, an amnestic response to other vaccines and unrelated fevers in case of patients who have had prior infection or immunization may give a false result.
3.Agglutinins usually appear by the end of the first week of infection, blood sample taken earlier may give a negative result.
4.Arising titre is more significant than a single high titre. It is therefore necessary to evaluate two or more serum samples taken at 4- 6 days intervals after the onset of the disease.
5.'O' being a somatic antigen brings about a coarse, compact,granular agglutination Whereas 'H' being a flagellar antigen brings about larger, loose, flocculant agglutination.
.